Semax (10mg)

# Semax - Cognitive Research Peptide

## SCIENTIFIC OVERVIEW
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment ACTH(4-10), originally developed at the Institute of Molecular Genetics, Russian Academy of Sciences. This neuropeptide has been extensively studied in neuroscience research for cognitive function, neuroprotection, and neurotransmitter system modulation.

## RESEARCH APPLICATIONS
Scientific investigations have explored Semax for:
- Brain-derived neurotrophic factor (BDNF) expression research
- Neurotrophic factor signaling pathway studies
- Dopaminergic and serotonergic system modulation research
- Hippocampal neuroplasticity mechanism analysis
- Attention and memory consolidation studies (animal models)
- Neuroprotection mechanism research (oxidative stress, ischemia)
- Neuroinflammation and cytokine modulation studies
- Acetylcholine and glutamate neurotransmitter research
- Stroke and traumatic brain injury models
- Cognitive enhancement mechanism investigation

## PRODUCT SPECIFICATIONS
- **Purity:** ≥98% (HPLC Verified)
- **Form:** Lyophilized Powder
- **Sequence:** Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- **Molecular Formula:** C₃₇H₅₁N₉O₁₀S
- **Molecular Weight:** 813.92 g/mol
- **CAS Number:** 80714-61-0
- **Appearance:** White to off-white powder
- **Solubility:** Water-soluble
- **Storage:** -20°C (freezer), protected from light
- **Shelf Life:** 36 months unopened; 30 days reconstituted at 2-8°C

## QUALITY VERIFICATION
✓ RP-HPLC purity ≥98%  
✓ Mass spectrometry confirmation (ESI-MS)  
✓ Amino acid sequencing verification  
✓ Peptide content assay (≥85%)  
✓ Endotoxin: <1.0 EU/mg (LAL test)  
✓ Sterility testing (USP <71>)  
✓ pH: 5.0-7.0 (reconstituted)  
✓ Moisture: <5%  

## MECHANISM OF INTEREST (Research Context)
Published studies indicate Semax modulates multiple neurobiological pathways:

**Neurotrophic Factors:**
- Upregulates BDNF mRNA and protein expression
- Increases NGF (nerve growth factor) in hippocampus
- Modulates neurotrophin receptor signaling

**Neurotransmitter Systems:**
- Enhances dopamine metabolism in nigrostriatal pathway
- Modulates serotonin turnover
- Affects enkephalin system
- Influences GABA and glutamate balance

**Neuroprotection:**
- Antioxidant enzyme activation (SOD, catalase)
- Reduces lipid peroxidation
- Inhibits pro-inflammatory cytokines
- Mitochondrial protection mechanisms

**Gene Expression:**
- Modulates immediate early gene expression (c-Fos, NGFI-A)
- Affects neurotransmitter-related gene transcription
- Influences synaptic plasticity gene regulation

## RESEARCH VARIANTS
**Semax (Standard):** 7 amino acids (this product)

**Semax-Acetate:** Salt form for enhanced stability

**N-Acetyl-Semax:** Acetylated variant with altered pharmacokinetics

**Semax Amidate:** C-terminal amidation for extended stability

This listing is for standard Semax unless otherwise specified.

## RECONSTITUTION GUIDELINES
1. Use sterile water, bacteriostatic water, or sterile saline
2. Typical concentration: 0.5-2.0 mg/mL
3. Add diluent slowly down vial wall
4. Swirl gently to dissolve (avoid vigorous agitation)
5. Solution should be clear and colorless
6. pH should be approximately 5.5-7.0
7. Filter through 0.22μm if needed for sterility assurance

## STABILITY DATA
- **Lyophilized powder:** 36 months at -20°C
- **Room temperature (sealed):** 60-90 days
- **Reconstituted:** 30 days at 2-8°C
- **pH stability:** Stable pH 4-8
- **Temperature:** Avoid prolonged exposure >25°C

## SCIENTIFIC BACKGROUND
Developed in Russia in the 1980s, Semax has been the subject of over 300 published studies. Research spans neurology, psychiatry, cognitive neuroscience, and neuroprotection. Extensive preclinical and clinical research conducted primarily in Russia and Eastern Europe.

## ADMINISTRATION ROUTES (Research Models)
Published literature reports various routes:
- **Intranasal:** Most common in animal and clinical studies
- **Subcutaneous:** Used in some rodent research
- **Intraperitoneal:** Animal model administration
- **Intracerebroventricular:** Specialized neuroscience research

## COMPARATIVE PEPTIDE RESEARCH
**vs. Selank:** Related peptide, more anxiolytic profile in studies

**vs. P21 (Cerebrolysin):** Different mechanism, Semax more BDNF-focused

**vs. Noopept:** Similar cognitive research applications, different structure

**vs. Dihexa:** Different potency profile, distinct mechanism

## RESEARCH DOSING CONTEXT
Literature reports wide dosing range depending on:
- Animal species and model
- Route of administration
- Study duration and objectives
- Acute vs. chronic administration protocols

Consult specific published studies for detailed methodology.

## HANDLING REQUIREMENTS
- Use sterile technique during reconstitution
- Work in clean environment or biosafety cabinet
- Wear appropriate PPE (gloves, lab coat, eye protection)
- Avoid skin contact and inhalation
- Store in clearly labeled containers
- Dispose according to institutional protocols

## REGULATORY STATUS
Semax is not approved by FDA for human use. Registered as a pharmaceutical in Russia and some CIS countries for research and medical use. In most jurisdictions, classified as a research chemical for laboratory use only.

## FOR RESEARCH PURPOSES ONLY
This product is intended strictly for in-vitro research and laboratory animal studies. Not for human consumption or self-administration. Not a dietary supplement or nootropic product. Requires institutional oversight and appropriate animal research approvals.

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**DISCLAIMER:** By purchasing, you certify you are a qualified neuroscience researcher conducting legitimate scientific investigation. Purchaser assumes all responsibility for compliance with institutional animal care protocols, biosafety requirements, and applicable laws and regulations.