Selank (10mg)

# Selank - Anxiolytic Research Peptide

## SCIENTIFIC OVERVIEW
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with a C-terminal Pro-Gly-Pro extension. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences), this peptide has been extensively studied in anxiety research, neurotransmitter modulation, and immune system interaction with the nervous system.

## RESEARCH APPLICATIONS
Laboratory studies have investigated Selank for:
- Anxiolytic mechanism research (animal behavioral models)
- GABAergic neurotransmission modulation studies
- Serotonin system pathway analysis
- Enkephalin metabolism research
- Immunomodulatory neuropeptide interactions
- Stress response and HPA axis studies
- Learning and memory research (non-stress paradigms)
- Neuroinflammation and cytokine modulation
- Gene expression in anxiety-related brain regions
- Synaptic plasticity mechanism investigation

## PRODUCT SPECIFICATIONS
- **Purity:** ≥98% (HPLC Verified)
- **Form:** Sterile Lyophilized Powder
- **Sequence:** Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
- **Molecular Formula:** C₃₃H₅₇N₁₁O₉
- **Molecular Weight:** 751.87 g/mol
- **CAS Number:** 129954-34-3
- **Appearance:** White to off-white powder
- **Solubility:** Highly water-soluble
- **Storage:** -20°C (freezer), desiccated
- **Shelf Life:** 36 months frozen; 30-60 days reconstituted at 2-8°C

## QUALITY ASSURANCE
✓ RP-HPLC purity ≥98%  
✓ Mass spectrometry confirmation  
✓ Amino acid composition analysis  
✓ Peptide content: ≥85%  
✓ Endotoxin: <1.0 EU/mg (LAL)  
✓ Sterility: USP <71> compliant  
✓ pH: 5.5-7.5 (reconstituted)  
✓ Residual solvents: <0.1%  

## MECHANISM OF ACTION (Research Models)
Published research indicates Selank affects multiple neurotransmitter and neuromodulator systems:

**GABAergic System:**
- Modulates GABA metabolism
- Influences benzodiazepine receptor binding
- Affects GABA transaminase activity

**Monoaminergic Systems:**
- Serotonin metabolism modulation (5-HT turnover)
- Dopamine system interactions
- Norepinephrine pathway effects

**Enkephalin System:**
- Inhibits enkephalin-degrading enzymes
- Increases endogenous enkephalin levels
- Modulates opioid peptide metabolism

**Immune-Nervous System Interface:**
- Cytokine expression modulation (IL-6, TNF-α)
- Immune cell receptor interactions
- Neuroimmune signaling research

**Gene Expression:**
- c-Fos expression in anxiety-related brain regions
- BDNF mRNA modulation
- Immediate early gene regulation

## RESEARCH BEHAVIORAL MODELS
Selank has been studied in various animal behavioral paradigms:
- Elevated plus maze (EPM)
- Open field test
- Light-dark box
- Social interaction tests
- Conditioned fear responses
- Morris water maze (cognitive aspects)

## COMPARATIVE PROFILE
**vs. Semax:** Related structure, Selank more anxiolytic-focused research

**vs. Tuftsin:** Parent peptide, Selank has extended sequence and CNS penetration

**vs. Benzodiazepines:** Different mechanism, no direct GABA-A agonism

**vs. SSRIs:** Acute effects in animal models vs. chronic antidepressant mechanisms

## RECONSTITUTION PROTOCOL
1. Allow vial to equilibrate to room temperature
2. Use bacteriostatic water or sterile saline
3. Typical concentration: 1-2 mg/mL for research
4. Add diluent slowly to minimize foaming
5. Swirl gently in circular motion
6. Allow 2-5 minutes for complete dissolution
7. Inspect for clarity (should be clear, colorless)
8. pH should be approximately 6-7

## STABILITY CHARACTERISTICS
- **Powder form:** Highly stable, 36+ months at -20°C
- **Room temperature (sealed):** 60-90 days
- **Reconstituted:** 30 days at 2-8°C; 60 days with bacteriostatic water
- **pH range:** Stable pH 4-9
- **Enzymatic resistance:** Enhanced vs. tuftsin (Pro-Gly-Pro extension)

## ADMINISTRATION ROUTES (Research Literature)
Most commonly studied routes:
- **Intranasal:** Primary route in published studies
- **Intraperitoneal:** Common in rodent research
- **Subcutaneous:** Used in some animal protocols
- **Oral:** Limited
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