Ipamorelin (10mg)

# Ipamorelin - Growth Hormone Secretagogue Research Peptide

## SCIENTIFIC OVERVIEW
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) classified as a selective growth hormone secretagogue receptor (GHS-R1a/ghrelin receptor) agonist. This compound demonstrates high selectivity for growth hormone release without significant ACTH or cortisol stimulation in research models, making it valuable for studying selective GH secretagogue pathways.

## RESEARCH APPLICATIONS
Laboratory studies have investigated Ipamorelin for:
- Ghrelin receptor (GHS-R1a) binding and activation research
- Selective GH secretion mechanism studies
- Pituitary somatotroph cell signaling analysis
- Growth hormone pulse amplitude research
- Hypothalamic-pituitary-somatotropic axis studies
- Age-related GH secretion decline models
- Synergistic GHRH/GHRP pathway research
- Appetite and metabolism regulation studies (ghrelin system)
- Bone density and osteoblast activity research

## PRODUCT SPECIFICATIONS
- **Purity:** ≥98% (HPLC Verified)
- **Form:** Lyophilized White Powder
- **Sequence:** Aib-His-D-2-Nal-D-Phe-Lys-NH₂
- **Molecular Formula:** C₃₈H₄₉N₉O₅
- **Molecular Weight:** 711.85 g/mol
- **CAS Number:** 170851-70-4
- **Appearance:** White to off-white sterile powder
- **Storage:** -20°C, protected from light and moisture
- **Reconstitution:** Bacteriostatic water or sterile saline
- **Shelf Life:** 24 months frozen; 30-60 days reconstituted at 2-8°C

## QUALITY CONTROL
✓ RP-HPLC purity ≥98%  
✓ Mass spectrometry verification (ESI-MS)  
✓ Amino acid composition analysis  
✓ Peptide content assay  
✓ Endotoxin testing: <0.5 EU/mg (LAL)  
✓ Sterility verification (USP <71>)  
✓ pH: 6.0-7.5 (reconstituted)  
✓ Moisture content: <3%  

## RECEPTOR SELECTIVITY
**High Selectivity Profile:**
- **GHS-R1a (Ghrelin Receptor):** Strong agonist (EC₅₀ ~1-10 nM)
- **ACTH secretion:** Minimal stimulation
- **Cortisol release:** No significant elevation
- **Prolactin:** Minimal effect
- **Other receptors:** Minimal cross-reactivity

This selectivity distinguishes Ipamorelin from less selective secretagogues (e.g., GHRP-6, GHRP-2).

## MECHANISM OF ACTION (Research Context)
Ipamorelin activates GHS-R1a receptors on:
1. **Anterior pituitary somatotrophs** → GH release
2. **Hypothalamic arcuate nucleus** → GHRH neuron activation
3. **Peripheral tissues** → Ghrelin system research

Signaling cascades include:
- Gq protein-coupled pathway
- Phospholipase C activation
- IP₃/DAG second messengers
- Calcium mobilization
- PKC activation

## PHARMACOKINETIC PROPERTIES (Research Models)
- **Half-life:** Approximately 2-3 hours in rodent models
- **Tmax:** 15-30 minutes (peak GH response in studies)
- **Duration:** GH elevation persists 2-3 hours post-administration
- **Bioavailability:** Variable by route (parenteral routes in research)

## SYNERGISTIC RESEARCH
Published studies demonstrate enhanced GH release when combined with GHRH analogs:

**Ipamorelin + CJC-1295 (no DAC):**
- Dual pathway activation (ghrelin receptor + GHRH receptor)
- Synergistic GH pulse amplitude (>additive effect)
- Maintained pulsatile physiological pattern
- Most studied combination in literature

## RECONSTITUTION PROTOCOL
1. Allow vial to reach room temperature (avoid condensation)
2. Add bacteriostatic water slowly (typical: 2-3 mL)
3. Concentration: 0.5-1.0 mg/mL for research applications
4. Swirl gently in circular motion (do not shake)
5. Allow 3-5 minutes for complete dissolution
6. Solution should be clear and colorless
7. Filter through 0.22μm sterile filter if particulates present

## STABILITY CONSIDERATIONS
- **Frozen (-20°C):** 24+ months
- **Refrigerated powder (2-8°C):** 6 months
- **Room temperature (sealed):** 30-60 days
- **Reconstituted:** 30 days at 2-8°C; 60 days with bacteriostatic water
- **pH stability:** Most stable pH 6-8
- **Light sensitivity:** Minimal, but protect from direct sunlight

## COMPARATIVE SECRETAGOGUE RESEARCH
**vs. GHRP-6:**
- More selective (less ACTH/cortisol/prolactin stimulation)
- No appetite stimulation (GHRP-6 increases appetite)
- Cleaner GH selectivity profile

**vs. GHRP-2:**
- Similar GH potency
- Better selectivity (less cortisol elevation)
- Preferred for long-term studies

**vs. Hexarelin:**
- Less receptor desensitization in chronic studies
- More sustainable GH response over time

**vs. MK-677 (Ibutamoren):**
- Peptide vs. non-peptide small molecule
- Shorter half-life (pulsatile vs. sustained)
- Different administration requirements

## SCIENTIFIC LITERATURE
First characterized in 1998, Ipamorelin has been studied in over 100 published papers. Research applications include aging studies, growth hormone deficiency models, body composition research, and bone metabolism investigations.

## RESEARCH DOSING CONSIDERATIONS
Literature reports wide range of research doses depending on model organism, route, and study objectives. Consult specific published protocols for detailed methodology. Typically administered in pulsatile fashion to mimic physiological GH secretion patterns.

## HANDLING & STORAGE
- Use sterile technique during all handling
- Store in original sealed vial until use
- Protect from light (amber vials or foil wrap)
- Avoid repeated freeze-thaw cycles
- Aliquot reconstituted solutions for single-use when possible
- Dispose according to institutional peptide waste protocols

## REGULATORY STATUS
Ipamorelin is not approved for human use by FDA, EMA, or other regulatory agencies. Classified as a research chemical. Subject to institutional oversight and biosafety review. May be regulated under anti-doping regulations for athletic research.

## FOR RESEARCH PURPOSES ONLY
This product is intended exclusively for in-vitro research and laboratory animal studies under appropriate institutional animal care and use committee (IACUC) approval. Not for human consumption, clinical trials, or therapeutic applications.

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**LEGAL NOTICE:** By purchasing, you certify you are a qualified researcher conducting legitimate scientific investigation. Purchaser assumes all responsibility for compliance with applicable laws, regulations, institutional biosafety protocols, and animal research ethics requirements.