HGH (10mg)

# HGH (Sermorelin) - Research Grade Growth Hormone

## SCIENTIFIC OVERVIEW
Recombinant human growth hormone (rhGH), also known as somatropin, is a 191-amino acid single-chain polypeptide identical to endogenously produced pituitary growth hormone. This research-grade preparation is manufactured using recombinant DNA technology for endocrinology research, cell culture studies, and growth hormone pathway analysis.

## RESEARCH APPLICATIONS
Laboratory investigations include:
- Growth hormone receptor (GHR) binding studies
- IGF-1 pathway activation research
- JAK-STAT signaling mechanism analysis
- Protein synthesis pathway studies
- Lipolysis and lipid metabolism research
- Glucose homeostasis mechanism studies
- Bone metabolism and osteoblast research
- Muscle satellite cell proliferation studies
- Nitrogen retention and amino acid transport research

## PRODUCT SPECIFICATIONS
- **Purity:** ≥98% (SEC-HPLC)
- **Form:** Lyophilized Powder (recombinant)
- **Sequence:** 191 amino acids (native human sequence)
- **Molecular Weight:** 22,124 Da
- **CAS Number:** 12629-01-5
- **Source:** E. coli expression system
- **Appearance:** White sterile lyophilized powder
- **Storage:** 2-8°C (refrigerated) for unopened vials
- **Reconstitution:** Bacteriostatic water or sterile water
- **Stability:** 24 months refrigerated; 14 days reconstituted at 2-8°C

## ANALYTICAL CHARACTERIZATION
✓ SEC-HPLC purity analysis (≥98%)  
✓ RP-HPLC verification  
✓ SDS-PAGE molecular weight confirmation  
✓ Western blot identity verification  
✓ Bioassay activity testing  
✓ Endotoxin: <0.1 EU/μg (LAL)  
✓ Host cell protein: <100 ppm  
✓ DNA residuals: <10 pg/dose  
✓ Sterility: USP <71> compliant  

## BIOLOGICAL ACTIVITY
Measured via Nb2 cell proliferation assay or equivalent bioassay. Specific activity: ≥2.6 IU/mg protein. Activity expressed in International Units (IU) per WHO International Standard.

## FORMULATION DETAILS
Each vial contains:
- Somatropin (recombinant): [Specified amount]
- Excipients: Glycine, sodium phosphate (buffering agents)
- pH: 7.0-8.0 (reconstituted)
- No preservatives in research-grade formulation

## RECONSTITUTION PROTOCOL
1. Refrigerate vial and diluent to 2-8°C
2. Add diluent slowly down the vial wall
3. Swirl gently (DO NOT shake - causes aggregation)
4. Allow 5-10 minutes for complete dissolution
5. Solution should be clear and colorless
6. Inspect for particulates before use
7. Use immediately or store at 2-8°C for maximum 14 days

## RESEARCH BACKGROUND
rhGH has been studied for over 40 years in growth biology research. Key research areas include growth plate biology, aging studies, metabolic syndrome models, and tissue engineering applications.

## HANDLING PRECAUTIONS
Sensitive to shaking, temperature fluctuations, and light exposure. Maintain cold chain during shipping and storage. Avoid repeated freeze-thaw cycles which cause protein aggregation and loss of biological activity.

## REGULATORY STATUS
This is a research-grade preparation not intended for pharmaceutical or clinical use. Not FDA-approved for human administration outside clinical trials. Subject to DEA and institutional oversight regulations.

## FOR RESEARCH PURPOSES ONLY
Intended exclusively for qualified laboratory research, cell culture studies, and in-vitro applications. Not for human consumption or therapeutic use. Requires institutional biosafety approval.

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**WARNING:** rhGH is a controlled substance in many jurisdictions. Purchaser certifies compliance with all applicable laws including 21 CFR Part 1300-1316 and institutional biosafety protocols. Misuse may result in serious legal consequences.