{"product_id":"yk-11-10mg-copy","title":"LGD-4033 (10mg per ml x 30ml)","description":"\u003cp\u003eLGD-4033 (commonly referred to as “Ligandrol”) is a nonsteroidal small-molecule compound described in the scientific literature as a\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eselective androgen receptor modulator (SARM)\u003c\/strong\u003e. In research contexts, SARMs are investigated for tissue-selective modulation of the\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eandrogen receptor (AR)\u003c\/strong\u003e, with the goal of studying anabolic signaling in muscle and bone while characterizing androgenic effects in other tissues. LGD-4033 has been examined in preclinical and controlled-study settings for AR binding activity, pharmacodynamic biomarker changes, and effects on lean mass–related endpoints, alongside safety and tolerability signals within study constraints. It is not broadly established as safe or effective for general human use outside approved medical contexts.\u003c\/p\u003e\n\u003ch2\u003eRESEARCH APPLICATIONS (Preclinical \/ Mechanistic)\u003c\/h2\u003e\n\u003cp\u003eScientific investigations have explored LGD-4033 and related SARMs for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAndrogen receptor binding affinity and selectivity assays\u003c\/li\u003e\n\u003cli\u003eAR transcriptional activity (reporter assays) and co-regulator recruitment research\u003c\/li\u003e\n\u003cli\u003eTissue-selective AR signaling studies (muscle vs. prostate model comparisons)\u003c\/li\u003e\n\u003cli\u003eMyogenesis and skeletal muscle protein turnover pathway research (cell\/animal models)\u003c\/li\u003e\n\u003cli\u003eBone biology studies (osteoblast\/osteoclast signaling, bone turnover markers in models)\u003c\/li\u003e\n\u003cli\u003eComparative pharmacology vs. testosterone\/DHT and other AR ligands\u003c\/li\u003e\n\u003cli\u003eEndocrine feedback investigations (HPG axis modulation in models\/controlled settings)\u003c\/li\u003e\n\u003cli\u003eADME\/PK characterization (absorption, distribution, metabolism, clearance in models)\u003c\/li\u003e\n\u003cli\u003eSafety pharmacology and toxicology screening (hepatic markers, lipids, CV signals)\u003c\/li\u003e\n\u003cli\u003eAnti-doping analytical method development (metabolite identification; detection windows)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMECHANISM OF ACTION (Research Context)\u003c\/h2\u003e\n\u003cp\u003eLGD-4033 is generally characterized as an androgen receptor ligand:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrimary target:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAndrogen receptor (AR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePutative action:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAR agonism with a “selective” or tissue-biased profile in some experimental systems\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDownstream effects studied:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAR-driven transcriptional programs associated with muscle maintenance, nitrogen balance, and bone remodeling pathways\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelectivity concept:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eDifferential tissue exposure and co-regulator recruitment may contribute to distinct signaling profiles vs. endogenous androgens in models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eQUALITY \/ IDENTITY VERIFICATION (Analytical)\u003c\/h2\u003e\n\u003cp\u003eFor research-grade chemical identity confirmation and documentation, common analytical approaches include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLC‑MS\/HRMS for molecular ion confirmation and impurity profiling\u003c\/li\u003e\n\u003cli\u003eNMR (¹H\/¹³C) for structural confirmation where feasible\u003c\/li\u003e\n\u003cli\u003eHPLC\/UPLC assay for purity and related substances\u003c\/li\u003e\n\u003cli\u003eResidual solvent analysis (GC) where applicable\u003c\/li\u003e\n\u003cli\u003eWater content testing where relevant (e.g., Karl Fischer)\u003c\/li\u003e\n\u003cli\u003eStability testing under specified storage conditions (temperature\/light\/humidity)\u003c\/li\u003e\n\u003cli\u003eBatch documentation and traceability (lot ID, COA linkage, handling logs)\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Halo Labs","offers":[{"title":"Default Title","offer_id":42986839081169,"sku":null,"price":79.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0668\/4511\/4577\/files\/ghk-cu__29_-removebg-preview.png?v=1772037461","url":"https:\/\/halolabs.us\/products\/yk-11-10mg-copy","provider":"Halo Labs","version":"1.0","type":"link"}