{"product_id":"rad-140-copy","title":"YK-11 (10MG per ml x 30ml)","description":"\u003cp\u003eYK-11 is a synthetic small-molecule compound frequently discussed in gray literature and online communities as a “SARM-like” androgen receptor (AR) ligand. In formal scientific contexts, YK-11 has been described in limited in vitro research as an AR-acting compound with atypical signaling characteristics compared with well-characterized steroidal and nonsteroidal AR ligands. It is also commonly associated (in secondary sources) with claims about\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emyostatin\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003emodulation; however, the evidence base is comparatively sparse, and much of the discourse extends beyond robust, replicated datasets. As such, YK-11 should be treated as an investigational research chemical with significant uncertainty regarding pharmacology, safety, and translational relevance.\u003c\/p\u003e\n\u003ch2\u003eRESEARCH APPLICATIONS (Preclinical \/ Mechanistic)\u003c\/h2\u003e\n\u003cp\u003eScientific investigations and mechanistic discussions have explored YK-11 for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAndrogen receptor binding and reporter (transactivation) assays\u003c\/li\u003e\n\u003cli\u003eComparative AR signaling vs. reference ligands (e.g., DHT\/testosterone in vitro)\u003c\/li\u003e\n\u003cli\u003eGene-expression profiling of AR-regulated transcripts in cell models\u003c\/li\u003e\n\u003cli\u003eMechanistic study of\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emyogenic differentiation\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003emarkers in vitro\u003c\/li\u003e\n\u003cli\u003eExploratory evaluation of\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emyostatin pathway\u003c\/strong\u003e–related readouts (often indirect)\u003c\/li\u003e\n\u003cli\u003eOff-target pharmacology screening (nuclear receptor \/ receptor panel studies)\u003c\/li\u003e\n\u003cli\u003eBasic ADME-relevant profiling in research settings (solubility, stability in matrices)\u003c\/li\u003e\n\u003cli\u003eAnalytical method development for identification\/impurity profiling (QC research)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMECHANISM OF ACTION (Research Context)\u003c\/h2\u003e\n\u003cp\u003eYK-11 is generally discussed as an androgen receptor–interacting compound:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrimary target (putative):\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAndrogen receptor (AR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePutative action:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAR agonism\/partial agonism with non-canonical signaling reported in some in vitro systems\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDownstream effects studied\/discussed:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAR-driven transcriptional programs related to myogenesis and muscle cell differentiation in cell models\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMyostatin-related claims:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eOften framed around changes in pathway markers (e.g., myostatin or associated regulators) in limited experimental contexts; the strength, reproducibility, and in vivo relevance of these findings are not well established\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eQUALITY \/ IDENTITY VERIFICATION (Analytical)\u003c\/h2\u003e\n\u003cp\u003eFor research-grade chemical identity confirmation and documentation, commonly used approaches include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLC-MS\/HRMS for molecular ion confirmation and impurity profiling\u003c\/li\u003e\n\u003cli\u003eNMR (¹H\/¹³C) for structural confirmation where feasible\u003c\/li\u003e\n\u003cli\u003eHPLC\/UPLC assay for purity and related substances\u003c\/li\u003e\n\u003cli\u003eResidual solvent analysis (GC) where applicable\u003c\/li\u003e\n\u003cli\u003eStability testing under defined storage conditions (light\/heat\/moisture sensitivity)\u003c\/li\u003e\n\u003cli\u003eBatch traceability practices (lot ID, COA linkage, documentation controls)\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Halo Labs","offers":[{"title":"Default Title","offer_id":42986836984017,"sku":null,"price":79.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0668\/4511\/4577\/files\/ghk-cu__28_-removebg-preview.png?v=1772037461","url":"https:\/\/halolabs.us\/products\/rad-140-copy","provider":"Halo Labs","version":"1.0","type":"link"}