{"product_id":"igf-1-lr3","title":"IGF-1 LR3 (5mg)","description":"\u003cp\u003e# IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-I)\u003c\/p\u003e\n\u003cp\u003e## SCIENTIFIC OVERVIEW\u003cbr\u003eIGF-1 LR3 is a synthetic 83-amino acid analog of human Insulin-Like Growth Factor-I (IGF-I) with an N-terminal extension of 13 amino acids and a glutamic acid substitution at position 3. This modification significantly reduces binding to IGF-binding proteins (IGFBPs), resulting in extended biological half-life and altered receptor kinetics for research applications.\u003c\/p\u003e\n\u003cp\u003e## RESEARCH APPLICATIONS\u003cbr\u003eScientific studies have investigated IGF-1 LR3 for:\u003cbr\u003e- IGF-1 receptor (IGF-1R) signaling research\u003cbr\u003e- PI3K\/Akt pathway activation studies\u003cbr\u003e- MAPK\/ERK signaling mechanism analysis\u003cbr\u003e- Muscle satellite cell proliferation research\u003cbr\u003e- Myoblast differentiation studies\u003cbr\u003e- Protein synthesis pathway analysis\u003cbr\u003e- Glucose uptake and GLUT4 translocation research\u003cbr\u003e- Cell culture growth optimization (serum replacement)\u003cbr\u003e- Tissue engineering scaffold studies\u003cbr\u003e- Apoptosis inhibition mechanism research\u003c\/p\u003e\n\u003cp\u003e## PRODUCT SPECIFICATIONS\u003cbr\u003e- **Purity:** ≥95% (RP-HPLC)\u003cbr\u003e- **Form:** Lyophilized Sterile Powder\u003cbr\u003e- **Sequence:** 83 amino acids (R3 analog)\u003cbr\u003e- **Molecular Weight:** ~9,200 Da\u003cbr\u003e- **Modification:** 13 AA N-terminal extension + Glu³ substitution\u003cbr\u003e- **CAS Number:** 946870-92-4\u003cbr\u003e- **Appearance:** White to off-white powder\u003cbr\u003e- **Storage:** -20°C (freezer), desiccated\u003cbr\u003e- **Reconstitution:** Acetic acid (0.1M) or bacteriostatic water\u003cbr\u003e- **Stability:** 24 months frozen; 30 days at 2-8°C (reconstituted)\u003c\/p\u003e\n\u003cp\u003e## QUALITY CONTROL\u003cbr\u003e✓ RP-HPLC purity ≥95%  \u003cbr\u003e✓ Mass spectrometry confirmation (ESI-MS)  \u003cbr\u003e✓ Amino acid composition analysis  \u003cbr\u003e✓ Peptide content assay  \u003cbr\u003e✓ Endotoxin testing: \u0026lt;1.0 EU\/mg  \u003cbr\u003e✓ Bioactivity assay (cell proliferation)  \u003cbr\u003e✓ IGFBP binding reduction verification  \u003cbr\u003e✓ pH: 3.0-4.5 (reconstituted in acidic vehicle)  \u003c\/p\u003e\n\u003cp\u003e## BIOCHEMICAL CHARACTERISTICS\u003cbr\u003e**Half-Life Extension:** Approximately 20-30 hours in research models (vs. 10-12 minutes for native IGF-1)\u003c\/p\u003e\n\u003cp\u003e**IGFBP Binding:** Reduced affinity (~80-90% reduction) allows greater free IGF-1 availability\u003c\/p\u003e\n\u003cp\u003e**Receptor Binding:** Maintains high affinity for IGF-1R with altered kinetics due to structural modification\u003c\/p\u003e\n\u003cp\u003e**Stability:** Enhanced stability in physiological conditions compared to native IGF-1\u003c\/p\u003e\n\u003cp\u003e## RECONSTITUTION GUIDELINES\u003cbr\u003eFor optimal stability:\u003cbr\u003e- **Option 1:** 0.1M acetic acid (pH 3-4) - most stable\u003cbr\u003e- **Option 2:** Bacteriostatic water with gentle acidification\u003cbr\u003e- **Concentration:** Typically 0.1-1.0 mg\/mL for research use\u003cbr\u003e- **Technique:** Add diluent slowly, swirl gently, avoid foaming\u003c\/p\u003e\n\u003cp\u003e## RESEARCH CONSIDERATIONS\u003cbr\u003eIGF-1 LR3 demonstrates superior performance in cell culture applications due to reduced IGFBP sequestration. Commonly used as serum substitute in stem cell research, myoblast cultures, and tissue engineering protocols.\u003c\/p\u003e\n\u003cp\u003e## SCIENTIFIC REFERENCES\u003cbr\u003eOver 200 published studies have utilized Long R3 IGF-I in research applications including muscle biology, aging research, wound healing, and metabolic studies. Notable use in animal models of muscle wasting and tissue repair.\u003c\/p\u003e\n\u003cp\u003e## STORAGE RECOMMENDATIONS\u003cbr\u003e- **Powder:** -20°C in original sealed vial with desiccant\u003cbr\u003e- **Reconstituted:** 2-8°C for up to 30 days (acidic pH)\u003cbr\u003e- **Aliquots:** Single-use aliquots recommended to avoid freeze-thaw\u003cbr\u003e- **Light:** Protect from direct light exposure\u003c\/p\u003e\n\u003cp\u003e## HANDLING PRECAUTIONS\u003cbr\u003eRequires sterile technique. Work in biosafety cabinet when handling powder. Avoid skin contact. Use appropriate PPE. Dispose according to institutional biohazard protocols.\u003c\/p\u003e\n\u003cp\u003e## FOR RESEARCH PURPOSES ONLY\u003cbr\u003eThis product is intended strictly for in-vitro research, cell culture applications, and laboratory animal studies. Not for human consumption or clinical use. Not a pharmaceutical or dietary supplement.\u003c\/p\u003e\n\u003cp\u003e---\u003c\/p\u003e\n\u003cp\u003e**DISCLAIMER:** By purchasing, you certify you are a qualified researcher with appropriate training in peptide handling and biosafety protocols. This compound must be used under institutional oversight and in compliance with all applicable regulations.\u003c\/p\u003e","brand":"Halo Labs","offers":[{"title":"Standard","offer_id":42975181275345,"sku":null,"price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0668\/4511\/4577\/files\/ghk-cu__17_-removebg-preview.png?v=1771451825","url":"https:\/\/halolabs.us\/products\/igf-1-lr3","provider":"Halo Labs","version":"1.0","type":"link"}