{"product_id":"bromantane","title":"Bromantane (10mg)","description":"\u003cp\u003e# Bromantane (Ladasten) - Adamantane Derivative Research Compound\u003c\/p\u003e\n\u003cp\u003e## SCIENTIFIC OVERVIEW\u003cbr\u003eBromantane (N-(4-bromophenyl)adamantan-2-amine) is a synthetic adamantane derivative developed in Russia as an actoprotector (performance-enhancing adaptogen) and anxiolytic compound. This unique molecule has been studied for its effects on dopaminergic neurotransmission, physical performance, immune function, and stress resistance in various research models.\u003c\/p\u003e\n\u003cp\u003e## RESEARCH APPLICATIONS\u003cbr\u003eScientific studies have investigated Bromantane for:\u003cbr\u003e- Dopamine and serotonin synthesis enzyme modulation\u003cbr\u003e- Tyrosine hydroxylase and tryptophan hydroxylase activity research\u003cbr\u003e- Physical performance and fatigue resistance studies\u003cbr\u003e- Anxiolytic mechanism analysis (animal behavioral models)\u003cbr\u003e- Immune system modulation research (neurasthenia models)\u003cbr\u003e- HPA axis and stress response pathway studies\u003cbr\u003e- Neurotransmitter turnover and metabolism research\u003cbr\u003e- Psychostimulant mechanism investigation (non-amphetamine)\u003cbr\u003e- Mitochondrial function and energy metabolism\u003cbr\u003e- Heat stress and environmental adaptation research\u003c\/p\u003e\n\u003cp\u003e## PRODUCT SPECIFICATIONS\u003cbr\u003e- **Purity:** ≥98% (HPLC Verified)\u003cbr\u003e- **Form:** White to Off-White Crystalline Powder\u003cbr\u003e- **Chemical Name:** N-(4-bromophenyl)adamantan-2-amine\u003cbr\u003e- **Molecular Formula:** C₁₆H₂₀BrN\u003cbr\u003e- **Molecular Weight:** 306.24 g\/mol\u003cbr\u003e- **CAS Number:** 87913-26-6\u003cbr\u003e- **Appearance:** White to cream-colored powder\u003cbr\u003e- **Solubility:** DMSO, ethanol, limited water solubility\u003cbr\u003e- **Storage:** Room temperature (15-30°C), protected from light and moisture\u003cbr\u003e- **Shelf Life:** 36 months in sealed, desiccated container\u003c\/p\u003e\n\u003cp\u003e## QUALITY CONTROL\u003cbr\u003e✓ HPLC purity ≥98%  \u003cbr\u003e✓ NMR spectroscopy (¹H and ¹³C)  \u003cbr\u003e✓ Mass spectrometry confirmation  \u003cbr\u003e✓ Melting point: 195-200°C  \u003cbr\u003e✓ Residual solvents: \u0026lt;0.5%  \u003cbr\u003e✓ Heavy metals: \u0026lt;10 ppm  \u003cbr\u003e✓ Microbiological testing  \u003cbr\u003e✓ Moisture content: \u0026lt;0.5%  \u003c\/p\u003e\n\u003cp\u003e## MECHANISM OF ACTION (Research Context)\u003cbr\u003eBromantane exhibits a unique multifactorial mechanism distinct from classical stimulants:\u003c\/p\u003e\n\u003cp\u003e**Neurotransmitter Synthesis Enzymes:**\u003cbr\u003e- **Tyrosine Hydroxylase (TH):** Upregulation increases dopamine synthesis capacity\u003cbr\u003e- **Tryptophan Hydroxylase (TPH):** Modulation affects serotonin production\u003cbr\u003e- **Mechanism:** Gene expression modulation rather than direct receptor agonism\u003c\/p\u003e\n\u003cp\u003e**Dopaminergic System:**\u003cbr\u003e- Increases dopamine synthesis in nigrostriatal pathway\u003cbr\u003e- No direct dopamine receptor binding (non-amphetamine mechanism)\u003cbr\u003e- Enhances dopamine turnover without depletion\u003cbr\u003e- Sustained effect without tolerance development in studies\u003c\/p\u003e\n\u003cp\u003e**Serotonergic System:**\u003cbr\u003e- Modulates serotonin synthesis\u003cbr\u003e- Anxiolytic effects potentially mediated via 5-HT pathway\u003cbr\u003e- Balanced dopamine\/serotonin modulation\u003c\/p\u003e\n\u003cp\u003e**GABAergic System:**\u003cbr\u003e- Indirect modulation contributing to anxiolytic profile\u003cbr\u003e- No direct benzodiazepine receptor binding\u003c\/p\u003e\n\u003cp\u003e**Immunomodulation:**\u003cbr\u003e- Affects immune cell activity\u003cbr\u003e- Modulates cytokine production\u003cbr\u003e- Neurasthenia and asthenic syndrome research\u003c\/p\u003e\n\u003cp\u003e## PHARMACOLOGICAL CLASSIFICATION\u003cbr\u003e**Actoprotector:** A class of compounds that enhance physical performance under adverse conditions without increasing oxygen consumption or heat production (differs from classical stimulants)\u003c\/p\u003e\n\u003cp\u003e**Anxiolytic:** Reduces anxiety-like behavior in animal models without sedation\u003c\/p\u003e\n\u003cp\u003e**Adaptogen:** Enhances resistance to stress (physical and psychological)\u003c\/p\u003e\n\u003cp\u003e## PHARMACOKINETIC PROPERTIES (Research Models)\u003cbr\u003e- **Absorption:** Oral bioavailability in animal models\u003cbr\u003e- **Tmax:** 2-3 hours (peak blood levels)\u003cbr\u003e- **Half-life:** Long-acting (metabolites may persist days)\u003cbr\u003e- **Metabolism:** Hepatic hydroxylation and conjugation\u003cbr\u003e- **Accumulation:** Some evidence of tissue accumulation with chronic dosing\u003cbr\u003e- **Duration:** Extended effects (24-48+ hours in some studies)\u003c\/p\u003e\n\u003cp\u003e## RESEARCH DIFFERENTIATORS\u003cbr\u003e**vs. Amphetamines:**\u003cbr\u003e- No dopamine release (synthesis increase instead)\u003cbr\u003e- No receptor agonism\u003cbr\u003e- No tolerance or dependence in chronic studies\u003cbr\u003e- Sustained rather than acute stimulant effects\u003c\/p\u003e\n\u003cp\u003e**vs. Modafinil:**\u003cbr\u003e- Different mechanism (enzyme modulation vs. DAT inhibition)\u003cbr\u003e- Anxiolytic properties (modafinil may cause anxiety)\u003cbr\u003e- Immunomodulatory effects\u003c\/p\u003e\n\u003cp\u003e**vs. Caffeine:**\u003cbr\u003e- No adenosine receptor antagonism\u003cbr\u003e- Longer duration\u003cbr\u003e- Different subjective effects in research\u003c\/p\u003e\n\u003cp\u003e**vs. Traditional Adaptogens (Rhodiola, etc.):**\u003cbr\u003e- Defined chemical structure\u003cbr\u003e- Specific enzyme targets\u003cbr\u003e- More dopaminergic focus\u003c\/p\u003e\n\u003cp\u003e## SCIENTIFIC BACKGROUND\u003cbr\u003eDeveloped in the 1980s by the Soviet military research program for performance enhancement in extreme conditions. Originally used by Russian military, athletes, and cosmonauts. Over 100 published studies in Russian and international literature.\u003c\/p\u003e\n\u003cp\u003e## RESEARCH MODELS\u003cbr\u003eBromantane has been studied in:\u003cbr\u003e- **Physical performance:** Forced swim test, treadmill endurance\u003cbr\u003e- **Anxiety:** Elevated plus maze, open field test\u003cbr\u003e- **Cognitive function:** Learning and memory tasks\u003cbr\u003e- **Heat stress:** Thermal tolerance studies\u003cbr\u003e- **Immune function:** Neurasthenia models, immune cell activity\u003cbr\u003e- **Chronic stress:** Long-term stress exposure models\u003c\/p\u003e\n\u003cp\u003e## DISSOLUTION PROTOCOL\u003cbr\u003eDue to limited water solubility:\u003cbr\u003e1. **DMSO:** Primary solvent, dissolves at 10-50 mg\/mL\u003cbr\u003e2. **Ethanol:** Dissolves at 5-20 mg\/mL\u003cbr\u003e3. **PEG-400:** Alternative for in vivo research\u003cbr\u003e4. **Aqueous suspension:** Use methylcellulose or CMC for oral gavage\u003c\/p\u003e\n\u003cp\u003eFor research solutions:\u003cbr\u003e- Prepare stock in DMSO (10-100 mM)\u003cbr\u003e- Dilute into aqueous vehicle immediately before use\u003cbr\u003e- Use co-solvent systems if needed (DMSO\/PEG\/saline)\u003c\/p\u003e\n\u003cp\u003e## STABILITY DATA\u003cbr\u003e- **Powder form:** Highly stable, 36+ months at room temperature\u003cbr\u003e- **DMSO solution:** Stable 12 months at -20°C\u003cbr\u003e- **Aqueous solutions:** Limited stability, prepare fresh\u003cbr\u003e- **Light sensitivity:** Minimal, but store in amber vials recommended\u003cbr\u003e- **Oxidation:** Stable under normal atmospheric conditions\u003c\/p\u003e\n\u003cp\u003e## RESEARCH DOSING CONTEXT\u003cbr\u003ePublished literature reports (animal models):\u003cbr\u003e- **Mice:** 10-50 mg\/kg (oral)\u003cbr\u003e- **Rats:** 5-25 mg\/kg (oral)\u003cbr\u003e- **Duration:** Acute (single dose) to chronic (weeks-months)\u003cbr\u003e- **Timing:** Often administered in morning (circadian considerations)\u003c\/p\u003e\n\u003cp\u003eHuman clinical studies (Russian literature):\u003cbr\u003e- 50-100 mg daily for neurasthenia and asthenic conditions\u003cbr\u003e- Duration: 2-4 weeks typical in published trials\u003c\/p\u003e\n\u003cp\u003e## COMPARATIVE RESEARCH TIMELINE\u003cbr\u003e- **1980s:** Development and military testing\u003cbr\u003e- **1990s:** Clinical trials for asthenia and performance\u003cbr\u003e- **2000s:** Registration as pharmaceutical in Russia (Ladasten®)\u003cbr\u003e- **2010s+:** International research interest, Western studies\u003c\/p\u003e\n\u003cp\u003e## ANTI-DOPING STATUS\u003cbr\u003e**WADA Status:** Bromantane is prohibited in-competition and out-of-competition as a stimulant (S6 category). Notable detection in Olympic athletes (1996 Atlanta Olympics). Relevant for sports science research contexts.\u003c\/p\u003e\n\u003cp\u003e## HANDLING \u0026amp; STORAGE\u003cbr\u003e- Store at room temperature in tightly sealed container\u003cbr\u003e- Protect from moisture (use desiccant)\u003cbr\u003e- Handle powder in well-ventilated area\u003cbr\u003e- Wear appropriate PPE (gloves, lab coat, safety glasses)\u003cbr\u003e- Avoid inhalation or skin contact\u003cbr\u003e- Clean spills with appropriate organic solvents\u003cbr\u003e- Dispose according to institutional chemical waste protocols\u003c\/p\u003e\n\u003cp\u003e## ANALYTICAL METHODS\u003cbr\u003eFor research verification and quantification:\u003cbr\u003e- **HPLC:** RP-HPLC with UV detection (254 nm)\u003cbr\u003e- **GC-MS:** Gas chromatography-mass spectrometry\u003cbr\u003e- **LC-MS\/MS:** For biological sample analysis\u003cbr\u003e- **NMR:** Structural confirmation and purity\u003c\/p\u003e\n\u003cp\u003e## REGULATORY STATUS\u003cbr\u003e**Russia:** Registered pharmaceutical (Ladasten®) for asthenia\u003cbr\u003e**United States:** Not FDA-approved; research chemical status\u003cbr\u003e**Europe:** Not EMA-approved; research use only\u003cbr\u003e**WADA:** Prohibited substance for competitive sports\u003cbr\u003e**Other jurisdictions:** Generally unscheduled but not approved for human use\u003c\/p\u003e\n\u003cp\u003e## RESEARCH SAFETY CONSIDERATIONS\u003cbr\u003ePublished toxicology studies indicate:\u003cbr\u003e- Wide safety margin in animal models\u003cbr\u003e- Low acute toxicity (LD₅₀ \u0026gt;1000 mg\/kg in rodents)\u003cbr\u003e- Chronic administration studies show good tolerability\u003cbr\u003e- No reports of severe adverse effects in clinical trials\u003c\/p\u003e\n\u003cp\u003e*Consult original toxicology literature for comprehensive safety data*\u003c\/p\u003e\n\u003cp\u003e## FOR RESEARCH PURPOSES ONLY\u003cbr\u003eThis product is intended exclusively for in-vitro research and laboratory animal studies under appropriate institutional oversight. Not for human consumption or self-administration. Not a pharmaceutical product or dietary supplement. Not for use by athletes subject to anti-doping regulations.\u003c\/p\u003e\n\u003cp\u003e---\u003c\/p\u003e\n\u003cp\u003e**WARNING:** Bromantane is prohibited by WADA and many sports organizations. Misuse in athletic contexts may result in sanctions. By purchasing, you certify you are a qualified researcher conducting legitimate scientific investigation. Purchaser assumes all responsibility for safe handling, proper storage, and compliance with institutional chemical safety protocols, animal research ethics requirements, anti-doping regulations, and applicable laws.\u003c\/p\u003e","brand":"Halo Labs","offers":[{"title":"Standard","offer_id":42975181504721,"sku":null,"price":80.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0668\/4511\/4577\/files\/ghk-cu__16_-removebg-preview.png?v=1771451607","url":"https:\/\/halolabs.us\/products\/bromantane","provider":"Halo Labs","version":"1.0","type":"link"}